Augmented BMP signaling commits cranial neural crest cells to a chondrogenic fate by suppressing autophagic β-catenin degradation

Cranial neural crest cells (CNCCs) are a population of multipotent stem cells that give rise to craniofacial bone and cartilage during development. Bone morphogenetic protein (BMP) signaling and autophagy have been individually implicated in stem cell homeostasis. Mutations that cause constitutive a...

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Veröffentlicht in:Sci Signal
Hauptverfasser: Yang, Jingwen, Kitami, Megumi, Pan, Haichun, Nakamura, Masako Toda, Zhang, Honghao, Liu, Fei, Zhu, Lingxin, Komatsu, Yoshihiro, Mishina, Yuji
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7936468/
https://ncbi.nlm.nih.gov/pubmed/33436499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaz9368
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