Augmented BMP signaling in the neural crest inhibits nasal cartilage morphogenesis by inducing p53-mediated apoptosis

Bone morphogenetic protein (BMP) signaling plays many roles in skull morphogenesis. We have previously reported that enhanced BMP signaling through the BMP type IA receptor (BMPR1A) in cranial neural crest cells causes craniosynostosis during postnatal development. Additionally, we observed that 55%...

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Detalles Bibliográficos
Publicado en:Development
Autores principales: Hayano, Satoru, Komatsu, Yoshihiro, Pan, Haichun, Mishina, Yuji
Formato: Artigo
Lenguaje:Inglês
Publicado: The Company of Biologists 2015
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4378250/
https://ncbi.nlm.nih.gov/pubmed/25742798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.118802
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