Bromodomain proteins regulate human cytomegalovirus latency and reactivation allowing epigenetic therapeutic intervention

Reactivation of human cytomegalovirus (HCMV) from latency is a major health consideration for recipients of stem-cell and solid organ transplantations. With over 200,000 transplants taking place globally per annum, virus reactivation can occur in more than 50% of cases leading to loss of grafts as w...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Groves, Ian J., Jackson, Sarah E., Poole, Emma L., Nachshon, Aharon, Rozman, Batsheva, Schwartz, Michal, Prinjha, Rab K., Tough, David F., Sinclair, John H., Wills, Mark R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2021
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7936348/
https://ncbi.nlm.nih.gov/pubmed/33619107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2023025118
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