Transient activation of human cytomegalovirus lytic gene expression during latency allows cytotoxic T cell killing of latently infected cells

Human cytomegalovirus (HCMV) latency in the myeloid lineage is maintained by repressive histone modifications around the major immediate early promoter (MIEP), which results in inhibition of the lytic viral life cycle. We now show that pharmacological inhibition of histone deacetylases (HDACs) relie...

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Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: Krishna, B. A., Lau, B., Jackson, S. E., Wills, M. R., Sinclair, J. H., Poole, E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4835774/
https://ncbi.nlm.nih.gov/pubmed/27091512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24674
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