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Transient activation of human cytomegalovirus lytic gene expression during latency allows cytotoxic T cell killing of latently infected cells

Human cytomegalovirus (HCMV) latency in the myeloid lineage is maintained by repressive histone modifications around the major immediate early promoter (MIEP), which results in inhibition of the lytic viral life cycle. We now show that pharmacological inhibition of histone deacetylases (HDACs) relie...

詳細記述

保存先:
書誌詳細
出版年:Sci Rep
主要な著者: Krishna, B. A., Lau, B., Jackson, S. E., Wills, M. R., Sinclair, J. H., Poole, E.
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4835774/
https://ncbi.nlm.nih.gov/pubmed/27091512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24674
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