Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages

Mitochondria are important regulators of macrophage polarisation. Here, we show that arginase-2 (Arg2) is a microRNA-155 (miR-155) and interleukin-10 (IL-10) regulated protein localized at the mitochondria in inflammatory macrophages, and is critical for IL-10-induced modulation of mitochondrial dyn...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Dowling, Jennifer K., Afzal, Remsha, Gearing, Linden J., Cervantes-Silva, Mariana P., Annett, Stephanie, Davis, Gavin M., De Santi, Chiara, Assmann, Nadine, Dettmer, Katja, Gough, Daniel J., Bantug, Glenn R., Hamid, Fidinny I., Nally, Frances K., Duffy, Conor P., Gorman, Aoife L., Liddicoat, Alex M., Lavelle, Ed C., Hess, Christoph, Oefner, Peter J., Finlay, David K., Davey, Gavin P., Robson, Tracy, Curtis, Annie M., Hertzog, Paul J., Williams, Bryan R. G., McCoy, Claire E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2021
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7936006/
https://ncbi.nlm.nih.gov/pubmed/33674584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21617-2
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