Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages

Mitochondria are important regulators of macrophage polarisation. Here, we show that arginase-2 (Arg2) is a microRNA-155 (miR-155) and interleukin-10 (IL-10) regulated protein localized at the mitochondria in inflammatory macrophages, and is critical for IL-10-induced modulation of mitochondrial dyn...

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Publicado no:Nat Commun
Main Authors: Dowling, Jennifer K., Afzal, Remsha, Gearing, Linden J., Cervantes-Silva, Mariana P., Annett, Stephanie, Davis, Gavin M., De Santi, Chiara, Assmann, Nadine, Dettmer, Katja, Gough, Daniel J., Bantug, Glenn R., Hamid, Fidinny I., Nally, Frances K., Duffy, Conor P., Gorman, Aoife L., Liddicoat, Alex M., Lavelle, Ed C., Hess, Christoph, Oefner, Peter J., Finlay, David K., Davey, Gavin P., Robson, Tracy, Curtis, Annie M., Hertzog, Paul J., Williams, Bryan R. G., McCoy, Claire E.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7936006/
https://ncbi.nlm.nih.gov/pubmed/33674584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21617-2
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