Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages

Mitochondria are important regulators of macrophage polarisation. Here, we show that arginase-2 (Arg2) is a microRNA-155 (miR-155) and interleukin-10 (IL-10) regulated protein localized at the mitochondria in inflammatory macrophages, and is critical for IL-10-induced modulation of mitochondrial dyn...

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Publicado en:Nat Commun
Autores principales: Dowling, Jennifer K., Afzal, Remsha, Gearing, Linden J., Cervantes-Silva, Mariana P., Annett, Stephanie, Davis, Gavin M., De Santi, Chiara, Assmann, Nadine, Dettmer, Katja, Gough, Daniel J., Bantug, Glenn R., Hamid, Fidinny I., Nally, Frances K., Duffy, Conor P., Gorman, Aoife L., Liddicoat, Alex M., Lavelle, Ed C., Hess, Christoph, Oefner, Peter J., Finlay, David K., Davey, Gavin P., Robson, Tracy, Curtis, Annie M., Hertzog, Paul J., Williams, Bryan R. G., McCoy, Claire E.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2021
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7936006/
https://ncbi.nlm.nih.gov/pubmed/33674584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21617-2
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