Arginase impedes the resolution of colitis by altering the microbiome and metabolome

Arginase 1 (Arg1), which converts l-arginine into ornithine and urea, exerts pleiotropic immunoregulatory effects. However, the function of Arg1 in inflammatory bowel disease (IBD) remains poorly characterized. Here, we found that Arg1 expression correlated with the degree of inflammation in intesti...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Baier, Julia, Gänsbauer, Maximilian, Giessler, Claudia, Arnold, Harald, Muske, Mercedes, Schleicher, Ulrike, Lukassen, Sören, Ekici, Arif, Rauh, Manfred, Daniel, Christoph, Hartmann, Arndt, Schmid, Benjamin, Tripal, Philipp, Dettmer, Katja, Oefner, Peter J., Atreya, Raja, Wirtz, Stefan, Bogdan, Christian, Mattner, Jochen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7598089/
https://ncbi.nlm.nih.gov/pubmed/32721946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI126923
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