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Arginase impedes the resolution of colitis by altering the microbiome and metabolome

Arginase 1 (Arg1), which converts l-arginine into ornithine and urea, exerts pleiotropic immunoregulatory effects. However, the function of Arg1 in inflammatory bowel disease (IBD) remains poorly characterized. Here, we found that Arg1 expression correlated with the degree of inflammation in intesti...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Baier, Julia, Gänsbauer, Maximilian, Giessler, Claudia, Arnold, Harald, Muske, Mercedes, Schleicher, Ulrike, Lukassen, Sören, Ekici, Arif, Rauh, Manfred, Daniel, Christoph, Hartmann, Arndt, Schmid, Benjamin, Tripal, Philipp, Dettmer, Katja, Oefner, Peter J., Atreya, Raja, Wirtz, Stefan, Bogdan, Christian, Mattner, Jochen
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2020
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7598089/
https://ncbi.nlm.nih.gov/pubmed/32721946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI126923
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