Transcription factor Fra-1 targets arginase-1 to enhance macrophage-mediated inflammation in arthritis

The polarization of macrophages is regulated by transcription factors, such as NF-κB and activator protein 1 (AP-1). In this manuscript, we delineated the role of the transcription factor Fos-related antigen 1 (Fra-1) during macrophage activation and development of arthritis. Network level interacti...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Hannemann, Nicole, Cao, Shan, Eriksson, Daniel, Schnelzer, Anne, Jordan, Jutta, Eberhardt, Martin, Schleicher, Ulrike, Rech, Jürgen, Ramming, Andreas, Uebe, Steffen, Ekici, Arif, Cañete, Juan D., Chen, Xiaoxiang, Bäuerle, Tobias, Vera, Julio, Bogdan, Christian, Schett, Georg, Bozec, Aline
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2019
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6597220/
https://ncbi.nlm.nih.gov/pubmed/30990796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI96832
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