Arginase impedes the resolution of colitis by altering the microbiome and metabolome

Arginase 1 (Arg1), which converts l-arginine into ornithine and urea, exerts pleiotropic immunoregulatory effects. However, the function of Arg1 in inflammatory bowel disease (IBD) remains poorly characterized. Here, we found that Arg1 expression correlated with the degree of inflammation in intesti...

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Dades bibliogràfiques
Publicat a:J Clin Invest
Autors principals: Baier, Julia, Gänsbauer, Maximilian, Giessler, Claudia, Arnold, Harald, Muske, Mercedes, Schleicher, Ulrike, Lukassen, Sören, Ekici, Arif, Rauh, Manfred, Daniel, Christoph, Hartmann, Arndt, Schmid, Benjamin, Tripal, Philipp, Dettmer, Katja, Oefner, Peter J., Atreya, Raja, Wirtz, Stefan, Bogdan, Christian, Mattner, Jochen
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7598089/
https://ncbi.nlm.nih.gov/pubmed/32721946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI126923
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