Conditionally immortalised leukaemia initiating cells co-expressing Hoxa9/Meis1 demonstrate microenvironmental adaptation properties ex vivo while maintaining myelomonocytic memory

Regulation of haematopoietic stem cell fate through conditional gene expression could improve understanding of healthy haematopoietic and leukaemia initiating cell (LIC) biology. We established conditionally immortalised myeloid progenitor cell lines co-expressing constitutive Hoxa9.EGFP and inducib...

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Gepubliceerd in:Sci Rep
Hoofdauteurs: Stahlhut, Maike, Ha, Teng Cheong, Takmakova, Ekaterina, Morgan, Michael A., Schwarzer, Adrian, Schaudien, Dirk, Eder, Matthias, Schambach, Axel, Kustikova, Olga S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2021
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7935976/
https://ncbi.nlm.nih.gov/pubmed/33674652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-84468-3
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