Conditionally immortalised leukaemia initiating cells co-expressing Hoxa9/Meis1 demonstrate microenvironmental adaptation properties ex vivo while maintaining myelomonocytic memory

Regulation of haematopoietic stem cell fate through conditional gene expression could improve understanding of healthy haematopoietic and leukaemia initiating cell (LIC) biology. We established conditionally immortalised myeloid progenitor cell lines co-expressing constitutive Hoxa9.EGFP and inducib...

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Publicado no:Sci Rep
Main Authors: Stahlhut, Maike, Ha, Teng Cheong, Takmakova, Ekaterina, Morgan, Michael A., Schwarzer, Adrian, Schaudien, Dirk, Eder, Matthias, Schambach, Axel, Kustikova, Olga S.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7935976/
https://ncbi.nlm.nih.gov/pubmed/33674652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-84468-3
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