psiCLIP reveals dynamic RNA binding by DEAH-box helicases before and after exon ligation

RNA helicases remodel the spliceosome to enable pre-mRNA splicing, but their binding and mechanism of action remain poorly understood. To define helicase-RNA contacts in specific spliceosomal states, we develop purified spliceosome iCLIP (psiCLIP), which reveals dynamic helicase-RNA contacts during...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Strittmatter, Lisa M., Capitanchik, Charlotte, Newman, Andrew J., Hallegger, Martina, Norman, Christine M., Fica, Sebastian M., Oubridge, Chris, Luscombe, Nicholas M., Ule, Jernej, Nagai, Kiyoshi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2021
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7935899/
https://ncbi.nlm.nih.gov/pubmed/33674615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21745-9
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