Population Pharmacokinetics of PEGylated Asparaginase in Children with Acute Lymphoblastic Leukemia: Treatment Phase Dependency and Predictivity in Case of Missing Data

BACKGROUND AND OBJECTIVES: The pharmacokinetics of polyethylene glycol-conjugated asparaginase (PEG-ASNase) are characterized by an increase in elimination over time, a marked increase in ASNase activity levels from induction to reinduction, and high inter- and intraindividual variability. A populat...

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Bibliographic Details
Published in:Eur J Drug Metab Pharmacokinet
Main Authors: Würthwein, Gudrun, Lanvers-Kaminsky, Claudia, Siebel, Christian, Gerß, Joachim, Möricke, Anja, Zimmermann, Martin, Stary, Jan, Smisek, Petr, Schrappe, Martin, Rizzari, Carmelo, Zucchetti, Massimo, Hempel, Georg, Wicha, Sebastian G., Boos, Joachim
Format: Artigo
Language:Inglês
Published: Springer International Publishing 2021
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Original Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7935823/
https://ncbi.nlm.nih.gov/pubmed/33595793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13318-021-00670-8
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