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Indoleamine-2,3-Dioxygenase 1 Deficiency Suppresses Seizures in Epilepsy
Background: Indoleamine-2,3-dioxygenase 1 (IDO1) is the initial and rate-limiting enzyme in the metabolism of tryptophan (TRP) to kynurenine (KYN). IDO1-dependent neurotoxic KYN metabolism plays a crucial role in the pathogenesis of many neurodegenerative disorders. However, the function of IDO1 in...
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| izdano v: | Front Cell Neurosci |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Frontiers Media S.A.
2021
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7935521/ https://ncbi.nlm.nih.gov/pubmed/33679331 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2021.638854 |
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