Indoleamine-2,3-Dioxygenase 1 Deficiency Suppresses Seizures in Epilepsy

Background: Indoleamine-2,3-dioxygenase 1 (IDO1) is the initial and rate-limiting enzyme in the metabolism of tryptophan (TRP) to kynurenine (KYN). IDO1-dependent neurotoxic KYN metabolism plays a crucial role in the pathogenesis of many neurodegenerative disorders. However, the function of IDO1 in...

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Detalhes bibliográficos
Publicado no:Front Cell Neurosci
Main Authors: Deng, Ning, Hu, Jiao, Hong, Yu, Ding, Yuewen, Xiong, Yifan, Wu, Zhiyong, Xie, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Cellular Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7935521/
https://ncbi.nlm.nih.gov/pubmed/33679331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2021.638854
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