FcγRIIB is a T cell checkpoint in antitumor immunity

In the setting of cancer, T cells upregulate coinhibitory molecules that attenuate TCR signaling and lead to the loss of proliferative capacity and effector function. Checkpoint inhibitors currently in clinical use have dramatically improved mortality from melanoma yet are not effective in all patie...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Farley, Clara R., Morris, Anna B., Tariq, Marvi, Bennion, Kelsey B., Potdar, Sayalee, Kudchadkar, Ragini, Lowe, Michael C., Ford, Mandy L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7934918/
https://ncbi.nlm.nih.gov/pubmed/33616086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.135623
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