FcγRIIB is a T cell checkpoint in antitumor immunity

In the setting of cancer, T cells upregulate coinhibitory molecules that attenuate TCR signaling and lead to the loss of proliferative capacity and effector function. Checkpoint inhibitors currently in clinical use have dramatically improved mortality from melanoma yet are not effective in all patie...

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Vydáno v:JCI Insight
Hlavní autoři: Farley, Clara R., Morris, Anna B., Tariq, Marvi, Bennion, Kelsey B., Potdar, Sayalee, Kudchadkar, Ragini, Lowe, Michael C., Ford, Mandy L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2021
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7934918/
https://ncbi.nlm.nih.gov/pubmed/33616086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.135623
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