Echinatin effectively protects against NLRP3 inflammasome–driven diseases by targeting HSP90

Aberrant activation of NLRP3 inflammasome has been implicated in a variety of human inflammatory diseases, but currently, no pharmacological NLRP3 inhibitor has been approved. In this study, we showed that echinatin, the ingredient of the traditional herbal medicine licorice, effectively suppresses...

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Bibliografische gegevens
Gepubliceerd in:JCI Insight
Hoofdauteurs: Xu, Guang, Fu, Shubin, Zhan, Xiaoyan, Wang, Zhilei, Zhang, Ping, Shi, Wei, Qin, Nan, Chen, Yuanyuan, Wang, Chunyu, Niu, Ming, Guo, Yuming, Wang, Jiabo, Bai, Zhaofang, Xiao, Xiaohe
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2021
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7934863/
https://ncbi.nlm.nih.gov/pubmed/33350984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.134601
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