Icariside I specifically facilitates ATP or nigericin-induced NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity

BACKGROUND: Epimedii Folium (EF) is commonly used for treating bone fractures and joint diseases, but the potential hepatotoxicity of EF limits its clinical application. Our previous study confirms that EF could lead to idiosyncratic drug-induced liver injury (IDILI) and hepatocyte apoptosis, but th...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Cell Commun Signal
Main Authors: Gao, Yuan, Xu, Guang, Ma, Li, Shi, Wei, Wang, Zhilei, Zhan, Xiaoyan, Qin, Nan, He, Tingting, Guo, Yuming, Niu, Ming, Wang, Jiabo, Bai, Zhaofang, Xiao, Xiaohe
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2021
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7879676/
https://ncbi.nlm.nih.gov/pubmed/33573688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-020-00647-1
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