Icariside I specifically facilitates ATP or nigericin-induced NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity

BACKGROUND: Epimedii Folium (EF) is commonly used for treating bone fractures and joint diseases, but the potential hepatotoxicity of EF limits its clinical application. Our previous study confirms that EF could lead to idiosyncratic drug-induced liver injury (IDILI) and hepatocyte apoptosis, but th...

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Dettagli Bibliografici
Pubblicato in:Cell Commun Signal
Autori principali: Gao, Yuan, Xu, Guang, Ma, Li, Shi, Wei, Wang, Zhilei, Zhan, Xiaoyan, Qin, Nan, He, Tingting, Guo, Yuming, Niu, Ming, Wang, Jiabo, Bai, Zhaofang, Xiao, Xiaohe
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2021
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7879676/
https://ncbi.nlm.nih.gov/pubmed/33573688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-020-00647-1
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