Echinatin effectively protects against NLRP3 inflammasome–driven diseases by targeting HSP90

Aberrant activation of NLRP3 inflammasome has been implicated in a variety of human inflammatory diseases, but currently, no pharmacological NLRP3 inhibitor has been approved. In this study, we showed that echinatin, the ingredient of the traditional herbal medicine licorice, effectively suppresses...

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Dades bibliogràfiques
Publicat a:JCI Insight
Autors principals: Xu, Guang, Fu, Shubin, Zhan, Xiaoyan, Wang, Zhilei, Zhang, Ping, Shi, Wei, Qin, Nan, Chen, Yuanyuan, Wang, Chunyu, Niu, Ming, Guo, Yuming, Wang, Jiabo, Bai, Zhaofang, Xiao, Xiaohe
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2021
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7934863/
https://ncbi.nlm.nih.gov/pubmed/33350984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.134601
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