Extraction of mRNA from stalled ribosomes by the Ski complex

The evolutionarily conserved Ski2-Ski3-Ski8 (Ski) complex containing the 3′→5′ RNA helicase Ski2 binds to 80S ribosomes near the mRNA entrance and facilitates 3′→5′ exosomal degradation of mRNA during ribosome-associated mRNA surveillance pathways. Here, we assayed Ski’s activity using an in vitro r...

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發表在:Mol Cell
Main Authors: Zinoviev, Alexandra, Ayupov, Rustam K., Abaeva, Irina S., Hellen, Christopher U. T., Pestova, Tatyana V.
格式: Artigo
語言:Inglês
出版: 2020
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7934606/
https://ncbi.nlm.nih.gov/pubmed/32006463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.01.011
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