Separation-related rapid nuclear transport of DNA/RNA heteroduplex oligonucleotide: unveiling distinctive intracellular trafficking

DNA/RNA heteroduplex oligonucleotide (HDO), composed of DNA/locked nucleic acid (LNA) antisense oligonucleotide (ASO) and complementary RNA, is a next-generation antisense therapeutic agent. HDO is superior to the parental ASO in delivering to target tissues, and it exerts a more potent gene-silenci...

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Vydáno v:Mol Ther Nucleic Acids
Hlavní autoři: Ono, Daisuke, Asada, Ken, Yui, Daishi, Sakaue, Fumika, Yoshioka, Kotaro, Nagata, Tetsuya, Yokota, Takanori
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Gene & Cell Therapy 2020
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7933600/
https://ncbi.nlm.nih.gov/pubmed/33738132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2020.11.022
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