Heterozygous APC germline mutations impart predisposition to colorectal cancer

Familial adenomatous polyposis (FAP) is an inherited syndrome caused by a heterozygous adenomatous polyposis coli (APC) germline mutation, associated with a profound lifetime risk for colorectal cancer. While it is well accepted that tumorigenic transformation is initiated following acquisition of a...

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Bibliografische gegevens
Gepubliceerd in:Sci Rep
Hoofdauteurs: Preisler, Livia, Habib, Aline, Shapira, Guy, Kuznitsov-Yanovsky, Liron, Mayshar, Yoav, Carmel-Gross, Ilana, Malcov, Mira, Azem, Foad, Shomron, Noam, Kariv, Revital, Hershkovitz, Dov, Ben-Yosef, Dalit
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2021
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7933349/
https://ncbi.nlm.nih.gov/pubmed/33664379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-84564-4
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