A critical role for fas-mediated off-target tumor killing in T cell immunotherapy

T cell-based therapies have induced cancer remissions, though most tumors ultimately progress, reflecting inherent or acquired resistance including antigen escape. Better understanding of how T cells eliminate tumors will help decipher resistance mechanisms. We used a CRISPR/Cas9 screen and identifi...

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Veröffentlicht in:Cancer Discov
Hauptverfasser: Upadhyay, Ranjan, Boiarsky, Jonathan A., Pantsulaia, Gvantsa, Svensson-Arvelund, Judit, Lin, Matthew J., Wroblewska, Aleksandra, Bhalla, Sherry, Scholler, Nathalie, Bot, Adrian, Rossi, John M., Sadek, Norah, Parekh, Samir, Baccarini, Alessia, Merad, Miriam, Brown, Brian D., Brody, Joshua D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7933082/
https://ncbi.nlm.nih.gov/pubmed/33334730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-20-0756
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