A critical role for fas-mediated off-target tumor killing in T cell immunotherapy

T cell-based therapies have induced cancer remissions, though most tumors ultimately progress, reflecting inherent or acquired resistance including antigen escape. Better understanding of how T cells eliminate tumors will help decipher resistance mechanisms. We used a CRISPR/Cas9 screen and identifi...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Cancer Discov
Autori principali: Upadhyay, Ranjan, Boiarsky, Jonathan A., Pantsulaia, Gvantsa, Svensson-Arvelund, Judit, Lin, Matthew J., Wroblewska, Aleksandra, Bhalla, Sherry, Scholler, Nathalie, Bot, Adrian, Rossi, John M., Sadek, Norah, Parekh, Samir, Baccarini, Alessia, Merad, Miriam, Brown, Brian D., Brody, Joshua D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7933082/
https://ncbi.nlm.nih.gov/pubmed/33334730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-20-0756
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi