HP1 proteins compact DNA into mechanically and positionally stable phase separated domains

In mammals, HP1-mediated heterochromatin forms positionally and mechanically stable genomic domains even though the component HP1 paralogs, HP1α, HP1β, and HP1γ, display rapid on-off dynamics. Here, we investigate whether phase-separation by HP1 proteins can explain these biological observations. Us...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Keenen, Madeline M, Brown, David, Brennan, Lucy D, Renger, Roman, Khoo, Harrison, Carlson, Christopher R, Huang, Bo, Grill, Stephan W, Narlikar, Geeta J, Redding, Sy
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2021
Assuntos:
Biochemistry and Chemical Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7932698/
https://ncbi.nlm.nih.gov/pubmed/33661100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.64563
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