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Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin

Gene silencing by heterochromatin is proposed to occur in part from the ability of HP1 proteins to spread across large regions of the genome, compact the underlying chromatin and recruit repressive activities(1–3). Here we identify a new property of the human HP1α protein: the ability to form phase-...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Larson, Adam G., Elnatan, Daniel, Keenen, Madeline M., Trnka, Michael J., Johnston, Jonathan B., Burlingame, Alma L., Agard, David A., Redding, Sy, Narlikar, Geeta J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5606208/
https://ncbi.nlm.nih.gov/pubmed/28636604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature22822
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