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A mathematical model of the role of aggregation in sonic hedgehog signalling

Effective regulation of the sonic hedgehog (Shh) signalling pathway is essential for normal development in a wide variety of species. Correct Shh signalling requires the formation of Shh aggregates on the surface of producing cells. Shh aggregates subsequently diffuse away and are recognised in rece...

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Vydáno v:PLoS Comput Biol
Hlavní autoři: Derrick, Daniel J. A., Wolton, Kathryn, Currie, Richard A., Tindall, Marcus John
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7932509/
https://ncbi.nlm.nih.gov/pubmed/33617524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1008562
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