Sildenafil-evoked photoreceptor oxidative stress in vivo is unrelated to impaired visual performance in mice

PURPOSE: The phosphodiesterase inhibitor sildenafil is a promising treatment for neurodegenerative disease, but it can cause oxidative stress in photoreceptors ex vivo and degrade visual performance in humans. Here, we test the hypotheses that in wildtype mice sildenafil causes i) wide-spread photor...

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Publicat a:PLoS One
Autors principals: Berkowitz, Bruce A., Podolsky, Robert H., Lins Childers, Karen, Saadane, Aicha, Kern, Timothy S., Roberts, Robin, Olds, Hailey, Joy, Joydip, Richards, Collin, Rosales, Tilman, Schneider, Michael, Schilling, Brennan, Orchanian, Arthur, Graffice, Emma, Sinan, Kenan, Qian, Haohua, Harp, Lamis
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2021
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7932139/
https://ncbi.nlm.nih.gov/pubmed/33661941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0245161
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