Sildenafil-evoked photoreceptor oxidative stress in vivo is unrelated to impaired visual performance in mice

PURPOSE: The phosphodiesterase inhibitor sildenafil is a promising treatment for neurodegenerative disease, but it can cause oxidative stress in photoreceptors ex vivo and degrade visual performance in humans. Here, we test the hypotheses that in wildtype mice sildenafil causes i) wide-spread photor...

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Vydáno v:PLoS One
Hlavní autoři: Berkowitz, Bruce A., Podolsky, Robert H., Lins Childers, Karen, Saadane, Aicha, Kern, Timothy S., Roberts, Robin, Olds, Hailey, Joy, Joydip, Richards, Collin, Rosales, Tilman, Schneider, Michael, Schilling, Brennan, Orchanian, Arthur, Graffice, Emma, Sinan, Kenan, Qian, Haohua, Harp, Lamis
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2021
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7932139/
https://ncbi.nlm.nih.gov/pubmed/33661941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0245161
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