Sildenafil-evoked photoreceptor oxidative stress in vivo is unrelated to impaired visual performance in mice

PURPOSE: The phosphodiesterase inhibitor sildenafil is a promising treatment for neurodegenerative disease, but it can cause oxidative stress in photoreceptors ex vivo and degrade visual performance in humans. Here, we test the hypotheses that in wildtype mice sildenafil causes i) wide-spread photor...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Berkowitz, Bruce A., Podolsky, Robert H., Lins Childers, Karen, Saadane, Aicha, Kern, Timothy S., Roberts, Robin, Olds, Hailey, Joy, Joydip, Richards, Collin, Rosales, Tilman, Schneider, Michael, Schilling, Brennan, Orchanian, Arthur, Graffice, Emma, Sinan, Kenan, Qian, Haohua, Harp, Lamis
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2021
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7932139/
https://ncbi.nlm.nih.gov/pubmed/33661941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0245161
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