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Navigating the Unnatural Reaction Space: Directed Evolution of Heme Proteins for Selective Carbene and Nitrene Transfer

[Image: see text] Despite the astonishing diversity of naturally occurring biocatalytic processes, enzymes do not catalyze many of the transformations favored by synthetic chemists. Either nature does not care about the specific products, or if she does, she has adopted a different synthetic strateg...

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Veröffentlicht in:Acc Chem Res
Hauptverfasser: Yang, Yang, Arnold, Frances H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2021
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7931446/
https://ncbi.nlm.nih.gov/pubmed/33491448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.accounts.0c00591
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