Characterization and Modeling of Reversible Antibody Self-Association Provide Insights into Behavior, Prediction, and Correction

Reversible antibody self-association, while having major developability and therapeutic implications, is not fully understood or readily predictable and correctable. For a strongly self-associating humanized mAb variant, resulting in unacceptable viscosity, the monovalent affinity of self-interactio...

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Dettagli Bibliografici
Pubblicato in:Antibodies (Basel)
Autori principali: Mieczkowski, Carl, Cheng, Alan, Fischmann, Thierry, Hsieh, Mark, Baker, Jeanne, Uchida, Makiko, Raghunathan, Gopalan, Strickland, Corey, Fayadat-Dilman, Laurence
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7931086/
https://ncbi.nlm.nih.gov/pubmed/33671864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antib10010008
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