Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action

Human Arginase 1 (hArg1) is a metalloenzyme that catalyzes the hydrolysis of l-arginine to l-ornithine and urea, and modulates T-cell-mediated immune response. Arginase-targeted therapies have been pursued across several disease areas including immunology, oncology, nervous system dysfunction, and c...

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Publicado no:Commun Biol
Main Authors: Palte, Rachel L., Juan, Veronica, Gomez-Llorente, Yacob, Bailly, Marc Andre, Chakravarthy, Kalyan, Chen, Xun, Cipriano, Daniel, Fayad, Ghassan N., Fayadat-Dilman, Laurence, Gathiaka, Symon, Greb, Heiko, Hall, Brian, Handa, Mas, Hsieh, Mark, Kofman, Esther, Lin, Heping, Miller, J. Richard, Nguyen, Nhung, O’Neil, Jennifer, Shaheen, Hussam, Sterner, Eric, Strickland, Corey, Sun, Angie, Taremi, Shane, Scapin, Giovanna
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8322407/
https://ncbi.nlm.nih.gov/pubmed/34326456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-02444-z
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