Crystal Structure and Characterization of Human Heavy-Chain Only Antibodies Reveals a Novel, Stable Dimeric Structure Similar to Monoclonal Antibodies

We report the novel crystal structure and characterization of symmetrical, homodimeric humanized heavy-chain-only antibodies or dimers (HC2s). HC2s were found to be significantly coexpressed and secreted along with mAbs from transient CHO HC/LC cotransfection, resulting in an unacceptable mAb develo...

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Pubblicato in:Antibodies (Basel)
Autori principali: Mieczkowski, Carl, Bahmanjah, Soheila, Yu, Yao, Baker, Jeanne, Raghunathan, Gopalan, Tomazela, Daniela, Hsieh, Mark, McCoy, Mark, Strickland, Corey, Fayadat-Dilman, Laurence
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7709113/
https://ncbi.nlm.nih.gov/pubmed/33266498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antib9040066
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