Targeting HIF2α-ARNT hetero-dimerisation as a novel therapeutic strategy for pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) is a destructive disease of the pulmonary vasculature often leading to right heart failure and death. Current therapeutic intervention strategies only slow disease progression. The role of aberrant hypoxia-inducible factor (HIF)2α stability and function in the i...

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Publicat a:Eur Respir J
Autors principals: Macias, David, Moore, Stephen, Crosby, Alexi, Southwood, Mark, Du, Xinlin, Tan, Huiling, Xie, Shanhai, Vassallo, Arlette, Wood, Alexander J.T., Wallace, Eli M., Cowburn, Andrew S.
Format: Artigo
Idioma:Inglês
Publicat: European Respiratory Society 2021
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7930471/
https://ncbi.nlm.nih.gov/pubmed/32972983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1183/13993003.02061-2019
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