HIF2α–arginase axis is essential for the development of pulmonary hypertension

Hypoxic pulmonary vasoconstriction is correlated with pulmonary vascular remodeling. The hypoxia-inducible transcription factors (HIFs) HIF-1α and HIF-2α are known to contribute to the process of hypoxic pulmonary vascular remodeling; however, the specific role of pulmonary endothelial HIF expressio...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Cowburn, Andrew S., Crosby, Alexi, Macias, David, Branco, Cristina, Colaço, Renato D. D. R., Southwood, Mark, Toshner, Mark, Crotty Alexander, Laura E., Morrell, Nicholas W., Chilvers, Edwin R., Johnson, Randall S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2016
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4978263/
https://ncbi.nlm.nih.gov/pubmed/27432976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1602978113
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