HIF2α–arginase axis is essential for the development of pulmonary hypertension

Hypoxic pulmonary vasoconstriction is correlated with pulmonary vascular remodeling. The hypoxia-inducible transcription factors (HIFs) HIF-1α and HIF-2α are known to contribute to the process of hypoxic pulmonary vascular remodeling; however, the specific role of pulmonary endothelial HIF expressio...

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書目詳細資料
發表在:Proc Natl Acad Sci U S A
Main Authors: Cowburn, Andrew S., Crosby, Alexi, Macias, David, Branco, Cristina, Colaço, Renato D. D. R., Southwood, Mark, Toshner, Mark, Crotty Alexander, Laura E., Morrell, Nicholas W., Chilvers, Edwin R., Johnson, Randall S.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2016
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4978263/
https://ncbi.nlm.nih.gov/pubmed/27432976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1602978113
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