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A Novel SOD1 Intermediate Oligomer, Role of Free Thiols and Disulfide Exchange
Wild-type human SOD1 forms a highly conserved intra-molecular disulfide bond between C57-C146, and in its native state is greatly stabilized by binding one copper and one zinc atom per monomer rendering the protein dimeric. Loss of copper extinguishes dismutase activity and destabilizes the protein,...
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| Yayımlandı: | Front Neurosci |
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| Asıl Yazarlar: | , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Frontiers Media S.A.
2021
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7930385/ https://ncbi.nlm.nih.gov/pubmed/33679289 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2020.619279 |
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