A critical period of neuronal activity results in aberrant neurogenesis rewiring hippocampal circuitry in a mouse model of epilepsy

In the mammalian hippocampus, adult-born granule cells (abGCs) contribute to the function of the dentate gyrus (DG). Disruption of the DG circuitry causes spontaneous recurrent seizures (SRS), which can lead to epilepsy. Although abGCs contribute to local inhibitory feedback circuitry, whether they...

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Vydáno v:Nat Commun
Hlavní autoři: Lybrand, Zane R., Goswami, Sonal, Zhu, Jingfei, Jarzabek, Veronica, Merlock, Nikolas, Aktar, Mahafuza, Smith, Courtney, Zhang, Ling, Varma, Parul, Cho, Kyung-Ok, Ge, Shaoyu, Hsieh, Jenny
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7930276/
https://ncbi.nlm.nih.gov/pubmed/33658509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21649-8
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