Immunogenicity of prime-boost protein subunit vaccine strategies against SARS-CoV-2 in mice and macaques

SARS-CoV-2 vaccines are advancing into human clinical trials, with emphasis on eliciting high titres of neutralising antibodies against the viral spike (S). However, the merits of broadly targeting S versus focusing antibody onto the smaller receptor binding domain (RBD) are unclear. Here we assess...

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Библиографические подробности
Опубликовано в: :Nat Commun
Главные авторы: Tan, Hyon-Xhi, Juno, Jennifer A., Lee, Wen Shi, Barber-Axthelm, Isaac, Kelly, Hannah G., Wragg, Kathleen M., Esterbauer, Robyn, Amarasena, Thakshila, Mordant, Francesca L., Subbarao, Kanta, Kent, Stephen J., Wheatley, Adam K.
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2021
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7930087/
https://ncbi.nlm.nih.gov/pubmed/33658497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21665-8
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