Embryonic Expression of Nras(G 12 D) Leads to Embryonic Lethality and Cardiac Defects

Ras proteins control a complex intracellular signaling network. Gain-of-function mutations in RAS genes lead to RASopathy disorders in humans, including Noonan syndrome (NS). NS is the second most common syndromic cause of congenital heart disease. Although conditional expression of the Nras(G12D/)(...

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Detalhes bibliográficos
Publicado no:Front Cell Dev Biol
Main Authors: You, Xiaona, Ryu, Myung-Jeom, Cho, Eunjin, Sang, Yanzhi, Damnernsawad, Alisa, Zhou, Yun, Liu, Yangang, Zhang, Jing, Lee, Youngsook
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7928391/
https://ncbi.nlm.nih.gov/pubmed/33681212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.633661
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