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SPRED1 deletion confers resistance to MAPK inhibition in melanoma
Functional evaluation of genetic lesions can discover a role in cancer initiation and progression and help develop novel therapeutic strategies. We previously identified the negative MAPK regulator SPRED1 as a novel tumor suppressor in KIT-driven melanoma. Here, we show that SPRED1 is also frequentl...
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| 出版年: | J Exp Med |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Rockefeller University Press
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7927430/ https://ncbi.nlm.nih.gov/pubmed/33306107 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20201097 |
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