SPRED1 deletion confers resistance to MAPK inhibition in melanoma

Functional evaluation of genetic lesions can discover a role in cancer initiation and progression and help develop novel therapeutic strategies. We previously identified the negative MAPK regulator SPRED1 as a novel tumor suppressor in KIT-driven melanoma. Here, we show that SPRED1 is also frequentl...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Exp Med
Egile Nagusiak: Ablain, Julien, Liu, Sixue, Moriceau, Gatien, Lo, Roger S., Zon, Leonard I.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Rockefeller University Press 2020
Gaiak:
Brief Definitive Report
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7927430/
https://ncbi.nlm.nih.gov/pubmed/33306107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20201097
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