Intact Glucocorticoid Receptor Dimerization Is Deleterious in Trauma-Induced Impaired Fracture Healing

Following severe trauma, fracture healing is impaired because of overwhelming systemic and local inflammation. Glucocorticoids (GCs), acting via the glucocorticoid receptor (GR), influence fracture healing by modulating the trauma-induced immune response. GR dimerization-dependent gene regulation is...

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Vydáno v:Front Immunol
Hlavní autoři: Hachemi, Yasmine, Rapp, Anna E., Lee, Sooyeon, Dorn, Ann-Kristin, Krüger, Benjamin T., Kaiser, Kathrin, Ignatius, Anita, Tuckermann, Jan
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7927427/
https://ncbi.nlm.nih.gov/pubmed/33679723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.628287
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