Hypoxia and Hypoxia-Inducible Factor-1α Regulate Endoplasmic Reticulum Stress in Nucleus Pulposus Cells: Implications of Endoplasmic Reticulum Stress for Extracellular Matrix Secretion

Endoplasmic reticulum (ER) stress is shown to promote nucleus pulposus (NP) cell apoptosis and intervertebral disc degeneration. However, little is known about ER stress regulation by the hypoxic disc microenvironment and its contribution to extracellular matrix homeostasis. NP cells were cultured u...

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Detalhes bibliográficos
Publicado no:Am J Pathol
Main Authors: Novais, Emanuel J., Choi, Hyowon, Madhu, Vedavathi, Suyama, Kaori, Anjo, Sandra I., Manadas, Bruno, Shapiro, Irving M., Salgado, António J., Risbud, Makarand V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2021
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7927276/
https://ncbi.nlm.nih.gov/pubmed/33307037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2020.11.012
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