N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization

Many immune responses depend upon activation of NF-κB, an important transcription factor in the elicitation of a cytokine response. Here we show that N4BP1 inhibits TLR-dependent activation of NF-κB by interacting with the NF-κB signaling essential modulator (NEMO, also known as IκB kinase γ) to att...

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Publicat a:Nat Commun
Autors principals: Shi, Hexin, Sun, Lei, Wang, Ying, Liu, Aijie, Zhan, Xiaoming, Li, Xiaohong, Tang, Miao, Anderton, Priscilla, Hildebrand, Sara, Quan, Jiexia, Ludwig, Sara, Moresco, Eva Marie Y., Beutler, Bruce
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7925594/
https://ncbi.nlm.nih.gov/pubmed/33654074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21711-5
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