تحميل...
Dihydroquinazolines enhance 20S proteasome activity and induce degradation of α-synuclein, an intrinsically disordered protein associated with neurodegeneration
Aggregates or oligomeric forms of many intrinsically disordered proteins (IDPs), including α-synuclein, are hallmarks of neurodegenerative diseases, like Parkinson’s and Alzheimer’s disease, and key contributors to their pathogenesis. Due to their disordered nature and therefore lack of defined drug...
محفوظ في:
| الحاوية / القاعدة: | Bioorg Med Chem Lett |
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| المؤلفون الرئيسيون: | , , , , , , , |
| التنسيق: | Artigo |
| اللغة: | Inglês |
| منشور في: |
2021
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7925381/ https://ncbi.nlm.nih.gov/pubmed/33513387 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2021.127821 |
| الوسوم: |
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