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Small Molecule Enhancement of 20S Proteasome Activity Targets Intrinsically Disordered Proteins

The 20S proteasome is the main protease for the degradation of oxidatively damaged and intrinsically disordered proteins. When accumulation of disordered or oxidatively damaged proteins exceeds proper clearance in neurons, imbalanced pathway signaling or aggregation occurs, which have been implicate...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Jones, Corey L., Njomen, Evert, Sjögren, Benita, Dexheimer, Thomas S., Tepe, Jetze J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5720355/
https://ncbi.nlm.nih.gov/pubmed/28719185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b00489
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