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Small Molecule Enhancement of 20S Proteasome Activity Targets Intrinsically Disordered Proteins
The 20S proteasome is the main protease for the degradation of oxidatively damaged and intrinsically disordered proteins. When accumulation of disordered or oxidatively damaged proteins exceeds proper clearance in neurons, imbalanced pathway signaling or aggregation occurs, which have been implicate...
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| Izdano u: | ACS Chem Biol |
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| Glavni autori: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2017
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5720355/ https://ncbi.nlm.nih.gov/pubmed/28719185 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b00489 |
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