Two RNA Tunnel Inhibitors Bind in Highly Conserved Sites in Dengue Virus NS5 Polymerase: Structural and Functional Studies

Dengue virus (DENV) NS5 RNA-dependent RNA polymerase (RdRp), an important drug target, synthesizes viral RNA and is essential for viral replication. While a number of allosteric inhibitors have been reported for hepatitis C virus RdRp, few have been described for DENV RdRp. Following a diverse compo...

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Veröffentlicht in:J Virol
Hauptverfasser: Arora, Rishi, Liew, Chong Wai, Soh, Tingjin Sherryl, Otoo, Dorcas Adobea, Seh, Cheah Chen, Yue, Kimberley, Nilar, Shahul, Wang, Gang, Yokokawa, Fumiaki, Noble, Christian G., Chen, Yen Liang, Shi, Pei-Yong, Lescar, Julien, Smith, Thomas M., Benson, Timothy E., Lim, Siew Pheng
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2020
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7925201/
https://ncbi.nlm.nih.gov/pubmed/32907977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01130-20
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